NRG1 Fusions in KRAS Wild-type Pancreatic Cancer (H021)
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.omicsdi.org/dataset/ega/EGAS00001002759
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资源简介：
We used whole-genome and transcriptome sequencing to identify clinically actionable gene fusions in young adults with KRAS wild-type (KRASwt) pancreatic ductal adenocarcinoma (PDAC). These alterations included recurrent NRG1 rearrangements predicted to drive PDAC development through aberrant ERBB receptor-mediated signaling, and pharmacologic ERBB inhibition resulted in clinical improvement and remission of liver metastases in two patients with NRG1-rearranged tumors that had proved resistant to standard treatment. Our findings demonstrate that systematic screening of KRASwt tumors for oncogenic fusion genes will substantially improve the therapeutic prospects for a sizeable fraction of PDAC patients.EGA study EGAS00001002759
创建时间：
2020-05-12
