Comparative transcriptomic study of skeletal muscles response to muscular dystrophy with myositis

Muscular dystrophy with myositis (mdm) is a severe degenerative muscle disease arising from a spontaneous mutaton at the N2A-PEVK junction of titin protein. The affected mice show a complex disease phenotype, and more organism-wide spread response compared to other myopathies. The project objectives forcus on undertanding the response pattetern of different skelelal muscles to mdm. Examin the transcriptomic resposne of mdm afected skeletal muscle compared to wildype in the B6C3Fe a/a-Ttnmdm/J +/+ mice