Single-cell profiling highlight pathogenic myeloid features in house dust mite-induced murine model of airway inflammation

Myeloid cells, particularly dendritic cells (DCs) and macrophages, play pivotal roles during asthma exacerbation by producing various cytokines and chemokines. However, the heterogeneity and function of these cells remains inadequately explored. In this study, we performed an established HDM-induced allergic asthma mouse model and generated a single-cell landscape on immune counterpart in lungPlease find the attached Seurat object stored in rds files. You can load them with R readRDS() function. IC.rds stores the immune cells' scRNA-seq profiles. `nonIC.rds` stores the non-immune cells' scRNA-seq profiles. You may refer to the ann210320 column in the metadata for cell type annotation reference.Please consider citing our work if this dataset is helpful to you:Liu, J., Lv, J., Chen, S., Ma, J., Yao, J., Yuan, Z., Yang, C., Li, X., Zhang, X., Zhu, Y., Zhang, J. and Wu, L. (2024), Single-cell profiling highlight pathogenic myeloid features in house dust mite-induced murine model of airway inflammation. Allergy. https://doi.org/10.1111/all.16156