A new Co(II) coordination polymer: crystal structure and treatment activity on viral myocarditis by reducing CVB3 virus burdens

This work presents the synthesis and characterization of a thiocyanato linked Co(II) coordination polymer [Co2L1(μ1,3-SCN)(η1SCN)]n (1) using potential multisite compartmental N,O donor Schiff base blocker ligand [N, N′-bis(3-methoxysalicylidenimino)-1,3-daminopropane] (H2L1) in presence of Co(OAc)2 and KSCN. The structural determination shows that complex 1 shows a 1D chain-like structure composed of binuclear {Co2} cluster-based unit. Furthermore, the nanoparticles of complex 1 were prepared by a green grinding approach, which has good water dispersibility. In addition, for nano 1, the treatment on the myocarditis induced by CVB3 virus was evaluated, and the mechanism was also discussed. Finally, the potential binding mode of the compound binding to VP1 indicated a potential binding site and regulation mechanism.