Dataset for meta-analysis and metaregression of published outcomes data on definitive radiotherapy with or without chemotherapy for locally advanced cervical cancer in patients with contraindications to cisplatin

We performed a systematic review and meta-analysis to examine the treatment outcomes in patients with locally advanced cervical cancer with contraindications to cisplatin, that were managed with definitive radiotherapy with or without chemotherapy. We then performed a metaregression to examine the effects of clinical and treatment variables on outcomes.

We identified eligible studies and extracted relevant data using a standardized data extraction template.

Table 1 summarizes the characteristics of the population or subgroup (including the nature of contraindication to cisplatin) and the intervention groups (radiotherapy, brachytherapy, and/or chemotherapy regimens) per each eligible study.

Table 2 summarizes our assessment of the risk of bias for each study using templates that were based on the CASP Critical Appraisal Checklists.

Tables 3 and 4 summarize the outcomes (tumor response, survival, compliance rates, and toxicity) for each intervention group.

Table 5 consolidates numerical data from Tables 1, 3, and 4, suitable for meta-analyses and meta-regression.

Table 6 is a composite database that contains the main template used in the preparation of the other datasets for the proportional meta-analyses and metaregression, given the variables and outcomes of interest.

Table 7 is a composite database that contains the datasets used for the comparative meta-analyses.

Figures 1 to 5b are Forests plots for pooled outcomes according to the intervention categories.

Figures 6a to 6f are Forest plots for pooled outcomes according to the use or non-use of chemotherapy and nodal boost.