Loss of DNA glycosylases promotes health span/neuroprotection in a C. elegans model of human tauopathy

We utilized a Caenorhabditis elegans (C. elegans) model of human tauopathy to investigate the role of DNA glycosylases (Ung-1 and Nth-1 knockout worms) in disease development and progression. We then performed gene expression profiling analysis using data obtained from RNA-seq of 12 different genotypes grown under normal conditions. Comparative gene expression profiling analysis of RNA-seq data for normal (N2), glysosylases mutant (Ung-1 and Nth-1), tau-aggregate worm (BR5270), anti-tau-aggregate (BR5271) and their cross with respective tau worms. We used ~5000 worms per sample, one sample per genotype.