Profiling of bedaquiline (BDQ) induced transcriptome suggests amino acid metabolism and stress responses as alternate mechanisms contributing to BDQ tolerance in Mycobacterium tuberculosis (Mtb).

Whole transcriptome analysis of BDQ resistant Mycobacterium tuberculosis isolates (n=6) and H37Rv after 72 hours of bedaquiline (BDQ) pressure (3.75 &#181g/ml). Exposed isolates were compared to unexposed controls at t= 72 hours to identify genes being differentially regulated due to BDQ stress.