Additional file 3 of Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health

Additional file 3: Table S1. Descriptive statistics for cognitive tests in Generation Scotland. Table S2. Descriptive statistics for cognitive tests in LBC1936. Table S3. Descriptive statistics for cognitive tests in LBC1921. Table S4. Descriptive statistics for brain MRI measures in LBC1936. Table S5. Descriptive statistics for Dementia. Table S6. Fit measures for measurement models of general cognition in all three cohorts. Table S7. Cognitive test loadings on General cognitive function in all three cohorts. Table S8. Fit measures for MRI measure of brain health measurement models in LBC1936. Table S9. Loadings for MRI measures of brain health onto intercept and slope in LBC1936. Table S10. Descriptive statistics for Generation Scotland covariates. Table S11. Descriptive statistics for LBC1936 covariates. Table S12. Descriptive statistics for LBC1921 covariates. Table S13. Results from cognitive function models in GS, LBC1936 and LBC1921. Table S14. Meta-analysis of cognitive function associations with 84 EpiScores in GS, LBC1921, and LBC1936. Table S15. Biological function and pathway look-up in UniProt and Reactome databases of significant protein EpiScores. Table S16. Results from cognitive change models in LBC1936 and LBC1921. Table S17. Summary of associations with cognitive function in all 3 cohorts. Table S18. Results from LBC1936 global MRI measures at baseline (intercept). Table S19. LBC1936 global MRI measures across four waves in association with 84 EpiScores. Table S20. Summary of LBC1936 EpiScore associations with MRI measures of Brain health. Table S21. Logistic regression analysis results testing EpiScore associations with binary dementia diagnosis in GS, LBC1936 and LBC1921. Table S22. coxPH analysis results testing associations between 84 EpiScores and time-to-dementia in GS and LBC1936. Table S23. Mixed effects cox analysis results testing associations between 84 EpiScores and time-to-dementia in GS while accounting for family structure. Table S24. Competing risk analysis results testing associations between 84 EpiScores and time-to-dementia while accounting for the competing event of all-cause mortality in GS and LBC1936. Table S25. Meta-analysis of dementia (binary) associations with 84 EpiScores in GS, LBC1921 and LBC1936. Table S26. Meta-analysis of EpiScore associations with time-to-dementia in GS and LBC1936.