p-PKR dimer phosphorylates CDK1

Cyclin-dependent kinase 1 (CDK1, CDC2), as subunit of a complex with Cyclin B, regulates and promotes multiple transitions in the cell cycle. Protein kinase R (PKR, EIF2AK2) phosphorylates CDK1 at Y4, marking it for subsequent ubiquitination and proteosomal degradation, leading to G2/M arrest and apoptosis, in particular under genotoxic conditions in cancer therapy, and as part of the antiviral response (Dagon et al, 2001; Yoon et al, 2010).

Cyclin-dependent kinase 1（CDK1，CDC2），作为与Cyclin B形成的复合体的亚基，调节并促进细胞周期中多种转变。蛋白质激酶R（PKR，EIF2AK2）在Y4位磷酸化CDK1，标记其随后进行泛素化和蛋白酶体降解，导致G2/M期阻滞和细胞凋亡，尤其是在癌症治疗中受到基因毒性条件的影响，以及作为抗病毒反应的一部分（Dagon等，2001；Yoon等，2010）。