Genome-wide identification and characterization of circular RNA m6A modification in pancreatic cancer. Homo sapiens

N6-methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells and play critical roles in cancer. While most related studies focus on m6A modifications in linear RNA, transcriptome-wide profiling and exploration of m6A modification in circular RNAs in cancer is still lacking. Here, we proposed a high-performance tools named Circm6A for the detection of m6A-circRNAs. Based on Circm6A results, we revealed the m6A-circRNAs genomic landscape of PDAC for the first time and shed new light on the regulatory aspect of circRNAs at the RNA epigenetic level.