Novel Chiral Thiourea Derived from Hydroquinine and l‑Phenylglycinol: An Effective Catalyst for Enantio- and Diastereoselective Aza-Henry Reaction
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https://figshare.com/articles/dataset/Novel_Chiral_Thiourea_Derived_from_Hydroquinine_and_l_Phenylglycinol_An_Effective_Catalyst_for_Enantio-_and_Diastereoselective_Aza-Henry_Reaction/14057798
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资源简介：
A series of chiral
thiourea bearing multiple H-bond donors derived from hydroquinine
has been reported. The aza-Henry reaction of isatin-derived ketimines
and long-chain nitroalkanes catalyzed by these chiral thioureas can
achieve high enantioselectivity (78–99% ee) and excellent diastereoselectivity
(up to 99:1). This work is the first report on long-chain nitroalkanes
as substrates with excellent diastereoselectivity in metal-free catalytic
systems.
创建时间：
2021-03-02
