Malignant Phyllodes Tumor: Report of Two Cases and Review of Literature

Phyllodes tumour (PT) is a rare biphasic breast neoplasm. It constitutes <1% of the entire tumours of the breast. Based on the World Health Organization’s (WHO) proposal, premised on multiple histological features, phyllodes tumour is categorized into benign, borderline, and malignant breast neoplasms. Malignant phyllodes tumour (MPT) is even a rarer neoplasm. It occurs more commonly in older patients. However, it can uncommonly occur in younger individuals. The transformation of benign phyllodes into malignant forms is extremely rare. Here, we present two cases of young females (aged 20 and 27 years, respectively) who individually presented with rapidly progressive breast lumps. The two breast lumps were huge while one was recurrent and underwent a malignant transformation in approximately 7 weeks intervals following an initial complete excision and histological diagnosis of benign PT. Indeed, even in young females below the modal/peak age of phyllodes, the suspicion should be high. Additionally, breast ultrasonography findings, although not common, can be highly suggestive of PT. Furthermore, every breast lump should be further evaluated, and even more so, histologically, irrespective of the patient’s age as our first patient had an excision without histology.叶状肿瘤（Phyllodes tumour, PT）是一种罕见的双相性乳腺肿瘤，占所有乳腺肿瘤的比例不足1%。根据世界卫生组织（World Health Organization, WHO）基于多项组织学特征提出的分类标准，叶状肿瘤可分为良性、交界性与恶性三类。恶性叶状肿瘤（Malignant Phyllodes Tumour, MPT）更为罕见，好发于老年患者，但也可罕见发生于年轻群体。良性叶状肿瘤恶变为恶性病变的情况极为罕见。本文报告2例年轻女性患者（分别为20岁和27岁），均以快速进展的乳腺肿块为首发表现。2例患者的乳腺肿块体积均较大，其中1例为复发病例，在首次完整切除并经组织学确诊为良性PT后约7周发生了恶性转化。事实上，即使在叶状肿瘤高发年龄以下的年轻女性群体中，也应保持高度警惕。此外，乳腺超声检查结果虽不具典型特征，但可高度提示PT。进一步而言，无论患者年龄如何，所有乳腺肿块均应接受进一步检查，尤其是组织学检查——正如本研究首名患者仅接受切除未行组织学检查的情况所示。

搜集汇总

背景与挑战

背景概述

该数据集是一篇关于恶性叶状肿瘤的医学病例报告和文献综述，重点关注两例年轻尼日利亚女性（20岁和27岁）的罕见病例。数据集揭示了叶状肿瘤的罕见性，特别是恶性形式，并强调了一例在良性肿瘤切除后快速发生恶性转化的特殊情况，突显了在年轻患者中对该疾病的高度怀疑和及时组织学评估的重要性。