Mesenchymal stem cell derived exosomal microRNA-34c-5p ameliorates renal pericyte activation by inhibiting core fucosylation. Mus musculus

Renal interstitial fibrosis is an incurable pathological lesion in progressive chronic kidney diseases. Myofibroblast proliferation and microvascular damage are two important events in RIF, and pericytes are a major source of myofibroblasts in the kidney. However, the underlying mechanisms remain poorly characterized. We report that core fucosylation , a post translational modification of proteins. Mesenchymal stem cell derived exosomes reside specifically in the obstructed kidney and deliver microRNA 34c to inhibit CF, reducing pericyte activation and renal fibrosis. Furthermore, we clarify that the CD81 and EGFR complex aids the entry of exosomal microRNA34c into pericytes.