A Critical Review on Flavonoids Used in Treatment of Various Cancers

Flavonoids are natural phenol compounds that form a large group of secondaryplant metabolites with interesting biological activities they are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. These natural products are well known for their beneficial effects on health and efforts are being made to isolate the ingredients so called flavonoid. Flavonoids are of particular interest as they have significant effects on human health. Flavonoids possess anti-cancer properties and they exert their curative effect by modulating different cell. Flavonoids have gained Importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents Promoting apoptosis in cancer cells. Increasing evidence shows that flavonoids can inhibit carcinogenesis via suppressing ROS Levels. Surprisingly, flavonoids can also trigger excessive oxidative stress, but this can also induce death of malignant cells. High dietary flavonoid intake has strongly been suggested to reduce the risk of numerous cancerentities in a large body of epidemiological studies. . In this review,a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed.