LPS cross-tolerance is not transferable.

Mice were divided into 4 groups containing 4 animals each. In the initial phase of this experiment, animals were intraperitoneally injected with 0.5 mL of PBS or with LPS (20 mg/kg) + PAF (5 μg/mouse). These animals were then anesthetized, and their blood was collected 1 h after treatment. In the second phase of this experiment, 100 μL of the serum obtained from the mice treated with PBS or LPS (20 mg/kg body wt) + PAF (5 μg/mouse) was intraperitoneally injected into the other 2 groups of mice 30 min before they were injected with PAF (5 μg/mouse). Half of the mice in the group that originally received PAF (5 μg/mouse) + LPS (20 mg/kg) survived, but the serum from these animals failed to protect the naive animals injected with PAF (5 μg/mouse) 30 min after receiving the serum. The results are representative of 3 individual trials.