A Comprehensive Genomic Study of Pediatric Malignancy

Malignancy remains the leading cause of disease-related death in children. DNA sequencing studies have shown a paucity of actionable genomic alterations and a low mutation burden across pediatric cancers at diagnosis. We perform a comprehensive genomic and epigenomic analysis of pediatric tumor and normal tissues using next-generation sequencing to identify molecular fingerprints and targets for diagnosis, prognosis, and development of novel therapeutic methods. This study also represents one of the largest of its type to date and provides a rich genomic dataset for the pediatric cancer research community.]]>
INCLUSION CRITERIA: Pediatric or adult subjects with one of the following: Diagnosis of any tumor, malignancy, pre-malignant disorder, or suspected premalignant familial syndromes, regardless of patient age. Biospecimens can be collected with minimal additional risk to the subject during sampling or procedures required for routine patient care. Human samples, specimens and data collected on IRB approved protocols that are now closed. Note: please contact study PI for information regarding study subject age range. EXCLUSION CRITERIA: None ]]>