TAM-Derived EVs Promote Tumor Progression in Gliomas by Regulating Treg Through BPI

Gliomas are the most common primary malignant brain tumors, and the immune cells in the tumor microenvironment (TME) play a crucial role in the initiation and progression of glioma. This study aims to explore the regulatory mechanism by which extracellular vesicles (EVs) derived from tumor-associated macrophages (TAMs) promote glioma progression by modulating regulatory T-cell (Treg) differentiation through single-cell and transcriptomic sequencing.