Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification

The GAstric Precancerous conditions Study (GAPS, NCT04191551) is a cross-sectional study of patients undergoing endoscopy who are at increased risk of gastric cancer. Enrolled patients are administered a standardized questionnaire, undergo clinical biopsy collection using the Sydney system, and consent for the collection of saliva, blood, and additional gastric tissue. All patients are scored for intestinal metaplasia using the operative link on gastric intestinal metaplasia (OLGIM) scoring system.]]>
Inclusion Criteria: Participants were between the ages of 35 and 84 and were enrolled for the following indications: Abdominal pain Dyspepsia Iron deficiency anemia Helicobacter pylori assessment Surveillance of known gastric intestinal metaplasia and evaluation for family history of gastric cancer Exclusion criteria: Inability to give consent Prior gastric surgery History of solid organ or bone marrow transplantation, gastroparesis, thrombocytopenia, or anticoagulant use. ]]>
Stanford IRB approval (#45077) obtained March 20, 2018. Actual enrollment began July 30, 2018. Open to enrollment as of May 22, 2024.]]>