The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs Descriptor: 6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... Authors: Watson, N.S, Adams, C, Belton, D, Brown, D, Burns-Kurtis, C.L, Chaudry, L, Chan, C, Convery, M.A, Davies, D.E, Exall, A.M, Harling, J.D, Irving, W.R, Irvine, S, Kleanthous, S, McLay, I.M, Pateman, A.J, Patikis, A.N, Roethka, T.J, Senger, S, Stelman, G.J, Toomey, J.R, West, R.I, Whittaker, C, Zhou, P, Young, R.J. Deposit date: 2011-02-02 Release date: 2011-03-16 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Discovery of Potent and Long-Acting Oral Factor Xa Inhibitors with Tetrahydroisoquinoline and Benzazepine P4 Motifs. Bioorg.Med.Chem.Lett., 21, 2011
含四氢异喹啉（tetrahydroisoquinoline）与苯并氮䓬（benzazepine）P4基序（P4 motif）的强效长效口服因子Xa（factor Xa）抑制剂的发现
描述符：6-氯-N-[(3S)-1-(5-氟-1,2,3,4-四氢异喹啉-6-基)-2-氧代吡咯烷-3-基]萘-2-磺酰胺、活化因子Xa重链、钙离子……
作者：Watson, N.S.、Adams, C.、Belton, D.、Brown, D.、Burns-Kurtis, C.L.、Chaudry, L.、Chan, C.、Convery, M.A.、Davies, D.E.、Exall, A.M.、Harling, J.D.、Irving, W.R.、Irvine, S.、Kleanthous, S.、McLay, I.M.、Pateman, A.J.、Patikis, A.N.、Roethka, T.J.、Senger, S.、Stelman, G.J.、Toomey, J.R.、West, R.I.、Whittaker, C.、Zhou, P.、Young, R.J.
提交日期：2011-02-02
发布日期：2011-03-16
最后修改日期：2024-10-16
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9埃（Å）
引用文献：《含四氢异喹啉与苯并氮䓬P4基序的强效长效口服因子Xa抑制剂的发现》，《Bioorg.Med.Chem.Lett.》，第21卷，2011年
创建时间：
2011-02-02
