Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation

Bioelectronic medicines are a growing medical device sector with numerous applications spanning neurologic, rehabilitation, cardiopulmonary, and pain applications. In many cases, therapeutic efficacy is limited by off-target activation of motor fibers which can cause unwanted, and sometimes painful, muscle activation. Owing to their large diameter and myelinated nature, motor fibers have lower activation thresholds than the small diameter fibers that are typically targeted for therapeutic applications. To address this limitation, achieving net selective activation of small diameter fibers has been an active area of neuromodulation research with numerous techniques developed to overcome the threshold differences between off-target and on-target fiber types. One such technique is the usage of high-frequency (HF) waveforms which has been previously demonstrated to block neural fibers in a fiber-size dependent manner in rodent models. Here, we investigated HF block during vagus nerve stimul..., , # Data from: Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation

## Description

Raw electrophysiologic and physiologic data for Nature Communications article, \"Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation\" by Cheng et al. at the University of Wisconsin-Madison. For accessing/reading the data we strongly recommend downloading and using the accompanying software package ([https://doi.org/10.5281/zenodo.17781109](https://doi.org/10.5281/zenodo.17781109)) which contains code for aligning the separate neural, muscle, and cardiac data streams based on the specific stimulation trial parameters using the stimulation indexing inherent to the TDT data format.

### File/Folder Structure:

**HFBlock_Analysis_Metadata.xlsx:** Excel file containing experimental metadata

* Worksheets:
* Pig Info: Contains weight, sex, date info for subjects.
* metaDF: Maps raw data folder to experim...,