Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

ChEBI2013-01-09 更新2026-07-21 收录

白血病分子分型

肿瘤细胞起源研究

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-43333 数据链接链接失效反馈

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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2013-01-09

Identification of epigenetic modifiers essential for growth and survival of AML1/ETO-positive leukemia

白血病分子分型

表观遗传靶点

Aberrant gene expression patterns in acute myeloid leukemia (AML) with balanced chromosomal translocations are often associated with direct or indirect dysregulation of epigenetic modifiers. Previousl

NIAID Data Ecosystem90

Gene expression profiling of CEBPA double and single mutant and CEBPA wild type AML.

白血病分子分型

CEBPA基因

Mutations in CCAAT/enhancer binding protein alpha (CEBPA) are seen in 5-14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations s

NIAID Data Ecosystem50

Additional file 2 of Identification of immune subtypes of Ph-neg B-ALL with ferroptosis related genes and the potential implementation of Sorafenib

白血病分子分型

铁死亡靶向治疗

Additional file 2: Table S2. Genomic mutation detection panel.

Figshare2024-02-26 更新40

Classifying leukemia types with chromatin conformation data (5C)

白血病分子分型

染色质构象

Background: Although genetic or epigenetic alterations have shown to affect the three-dimensional organization of genomes, the utility of chromatin conformation in the classification of human disease

NIAID Data Ecosystem50

Chromatin accessibility maps of chronic lymphocytic leukemia identify subtype-specific epigenome signatures and transcription regulatory networks. Homo sapiens

癌症表观遗传学

白血病分子分型

Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we

NIAID Data Ecosystem40

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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