Identification and analysis of genes for the resistance of Periplaneta americana small peptide on hydrogen peroxide- induced apoptosis of granular cells

Granular cell is a single-layer or multi-layer trophoblast cell that wraps oocytes, and plays a pivotal role in the issue of animal reproduction and female fertility. Follicular atresia is mainly manifested as granular cell apoptosis, which can cause infertility, ovarian dysfunction and other female diseases. Oxidative stress (H2O2) damages the development of follicles by inducing apoptosis of granular cells, reducing ovarian reserve and causing premature ovarian failure (POF). Therefore, starting from the apoptosis of granular cell, looking for a substance that significantly inhibits the apoptosis of human ovarian granulosa cells is expected to provide a new solution for the treatment of POF.