Supplementary data 2. The gene regulatory interactions of the NAFLD-SNPs within unaffected- and diseased-LGRN

We identified SNPs that are strongly in linkage disequilibrium (r2 >= 0.8) with the NAFLD-associated SNPs reported by GWAS. The gene regulatory interactions of the NAFLD-SNPs (GWAS + LD) were extracted from the LGRN (spatially constrained; derived from a cohort of NAFLD unaffected individuals) and an eQTL-gene network derived from liver samples from a cohort of NAFLD patients (diseased-LGRN).

本研究识别出与经全基因组关联研究（GWAS）报道的NAFLD相关SNPs呈现强连锁不平衡（r2≥0.8）的SNPs。从受空间约束的LGRN（由未受NAFLD影响的队列成员衍生）以及来自NAFLD患者队列的肝脏样本中衍生的eQTL-基因网络中，提取了NAFLD-SNPs（GWAS + LD）的基因调控相互作用。