Molecular and phenotypic changes in FLExDUX4 mice

We investigated differences in the quadriceps transcriptome of 13-week-old heterozygous B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj/J (FLExDUX4) mouse model of Facioscapulohumeral Muscular Dystrophy (FSHD) and their wild type (WT) littermates to determine if there were characterize the structural/functional adaptations to aerobic exercise training and their molecular foundations using RNA sequencing Comparative gene expression profiling analysis of RNA-seq data from the quadriceps of 13-week-oldmale FLExDUX4 and WT littermates. Samples were collected from n=3 FLExDUX4 mice and n= 3 WT mice.