TR-gnomAD

TR-gnomAD is a biobank-scale reference of 0.86 million TRs derived from 338,963 whole-genome sequencing (WGS) samples of diverse ancestries (39.5% non-European samples). TR-gnomAD offers critical insights into ancestry-specific disease prevalence using disparities in TR unit number frequencies among ancestries.TR-gnomAD是一项生物样本库级别的参考数据集，涵盖86万个可变数目串联重复序列（Tandem Repeats，TR），其数据源自338963份覆盖不同血统群体的全基因组测序（whole-genome sequencing, WGS）样本，其中非欧洲血统样本占比39.5%。该数据集可通过分析不同血统间TR单元数量频率的差异，为血统特异性疾病患病率的相关研究提供关键见解。