Additional file 10 of A novel small molecule, AS1, reverses the negative hedonic valence of noxious stimuli

Additional file 10: Supplementary Table 5. Brain regions specifically upregulated in the context of 2.5 µM AS1, both alone (at 28.5 °C) and under conditions of noxious heat (37.5 °C). The same information shown in Additional files 7 and 8, but for experiments utilizing 2.5 µM AS1. A complete list of all of the regions of interest (ROIs) identified from MAP-Mapping analysis of pERK/tERK-labeled brains of larval zebrafish that were incubated in 2.5 µM AS1 and exposed to noxious heat. The “Signal Specific to AS1 + Heat” was obtained by subtracting the net signal of the “AS1 Only” and “Heat Only” groups from the net signal of the “AS1 + Heat” group for each ROI. The “Net Signal in AS1 Only vs Control” was obtained by comparing the “AS1 Only” group to the control group. ROIs are ranked in order from highest to lowest signal.