Additional file 1 of Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis

Additional file 1: Table S1. Summary of GWAS data. Table S2. SNP based heritability estimated by LDSC. Table S3. Partitioned genetic correlation between BF% and 2 cardiac traits. Table S4. Novel loci in MTAG for single trait compared with GWAS. Table S5. GO biological process pathway analysis for BF% and HF. Table S6. GO biological process pathway analysis for BF% and CAD. Table S7. Reactome pathways analysis for BF% and HF. Table S8. Reactome pathways analysis for BF% and CAD. Table S9. List of credible set SNPs in each locus from fine mapping. For each of the 5 BF% and HF shared loci, the table lists all SNPs within 500 kb in the 99% credible sets that were calculated. Table S10. List of credible set SNPs in each locus from fine mapping. For each of the 16 BF% and CAD shared loci, the table lists all SNPs within 500 kb in the 99% credible sets that were calculated. Table S11. Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs associated with BF% and HF with directional effect (Pmeta < 5×10-8; single trait P < 0.05). Table S12. Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs associated with BF% and CAD with directional effect (Pmeta < 5×10-8; single trait P < 0.05). Table S13. Specific characteristics of genetic instruments of MR analysis of BF% levels upon CVD traits. Table S14. Specific characteristics of genetic instruments of MR analysis of CVDs upon BF% levels. Table S15. MR analysis between BF% and cardiac traits in a leave one out approach. Table S16. MR analysis between BF% and cardiac traits for a single snp. Table S17. Significant overlap transcriptome-wide association analysis results between BF% and CVDs. (FDR<0.05). Table S18. Significant single-tissue eQTL from GTEx for 3 representative gene between BF% and HF. Table S19. Significant single-tissue eQTL from GTEx for 8 representative gene between BF% and CAD.