AB5D mitigates UVB-induced erythema through the modulation of PGE2

Erythema, characterized by the redness of the skin, is a common skin reaction triggered by various endogenous and exogenous factors. This response is often a result of the activation of underlying biological mechanisms within the skin. The objective of this study is to investigate the potential benefits of applying a combination of well-established active ingredients namely Allantoin, Bisabolol, D-Panthenol, and Dipotassium Glycyrrhizinate (AB5D). These ingredients are often incorporated in skincare formulations to deliver specific benefits. Additionally, the study aims to elucidate the mechanisms by which these ingredients exert their combined actions to alleviate erythema. Through in-vitro experiments involving the application of AB5D to UVB-exposed keratinocytes, we have uncovered novel insights into the potential response mechanism of AB5D. We observed a significant downregulation of gene sets associated with inflammatory responses, highlighting the anti-inflammatory properties of AB5D. Specifically, AB5D effectively reduced the production of PGE2, leading to the downregulation of inflammatory cytokines. Moreover, our findings indicate that AB5D exhibits antioxidative capabilities, functioning as both an antioxidant agent and a regulator of antioxidant enzyme expression to counteract the detrimental effects of cellular oxidative stress. Overall, it is plausible to suggest that AB5D may alleviate erythema by modulating inflammation via PGE2 and through antioxidation mechanisms. Overall design: To evaluate the mechanism of action by which the combination of Allantoin, Bisabolol, D-Panthenol, and Dipotassium Glycyrrhizinate (AB5D) may exert benefical effects on UVB-exposed hTERT keratinocytes