Transcriptional and genomic occupancy profiling from MLX WT and MLX knockout mouse tissues.. Transcriptional and genomic occupancy profiling from MLX WT and MLX knockout mouse tissues.

We generated mice null for MAX-like Protein X (MLX), encoded by Mlx. All male mice are sterile. We profiled testes tissue from WT versus KO mice by RNA-Seq. We performed ChIP-Seq on WT and KO testes for MLX and MAX, as well as ChIP-Seq for MLX and MAX from primary B220+ splenic B cells, and ChIP-Seq for MLX, MAX and MNT from 3T3 cell lines derived from WT and KO embryos. Overall design: RNA-Seq and ChIP-Seq for MLX and MAX was performed on testes from MLX WT and MLX knockout (KO) mice. ChIP-Seq for MLX and MAX was performed on primary B220+ B cells from WT and KO mice. ChIP-Seq for MLX, MAX and MNT was performed on 3T3 cell ines derived from MLX WT and MLX KO embryos.