Investigation of the self-assembly process and supramolecular structures of a family of amino-acid based derivatives with potential connection with the development of amyloid-type structures.

In this project we propose to investigate the self-assembly processes and supramolecular aggregates of amino-acid-based derivatives, particularly those derived from L-Phenylalanine and L-Tyrosine using small-angle X-ray scattering (SAXS) experiments. These molecules have been modified through reactions with various aldehydes, allowing them to act as versatile building blocks with exciting supramolecular properties. The study aims to understand the aggregation mechanisms of these derivatives, focusing on their potential to form amyloid-like fibrils, structures linked to degenerative diseases such as Alzheimer’s and Parkinson’s.
Preliminary biological studies have also revealed the potential of some derivatives to promote neurostimulation, as evidenced by their interaction with mouse neuroblasts. Notably, several derivatives induced cell differentiation, a process rarely observed in existing literature, suggesting a possible neurostimulant activity. Further experiments are ongoing to correlate these supramolecular assemblies with amyloid-type fibrils, aiming to explore their applications as initiators, enhancers, or inhibitors of amyloid fibril formation.
Ultimately, the research seeks to provide a deeper understanding of the molecular and supramolecular structures of these amino-acid derivatives, paving the way for future studies on their biomedical applications, including neurodegenerative disease treatment.