Next generation pan-cancer blood proteome profiling using proximity extension assay

We have characterized the plasma proteome of a pan-cancer cohort from the Uppsala-Umeå Comprehensive Cancer Consortium (U-CAN) biobank (15), comprising 1,477 patients from twelve cancer types, including acute myeloid leukemia (n= 50), chronic lymphocytic leukemia (n= 48), diffuse large B-cell lymphoma (n= 55), myeloma (n= 38), colorectal cancer (n= 221), lung cancer (n= 268), glioma (n= 145), breast cancer (n= 152), cervical cancer (n= 102), endometrial cancer (n= 101), ovarian cancer (n= 134) and prostate cancer (n= 163). Plasma samples were collected at the time of diagnosis and before treatment were initiated, and measured in minute amounts of blood plasma. The dataset contains NPX values from Proximity Extension Assay analysis (Olink: https://www.olink.com/) for 1,463 proteins in 12 cancer types.