Dentin phosphoprotein binds integrin alphaVbeta1

DPP (also called “phosphophoryn”) is a highly acidic protein and is the major noncollagenous matrix component of dentin (13,–,15). The molecule is so-called because it is considered to be a “phosphate carrier” (16). DPP is exceedingly rich in aspartic acid and serine residues ((DSS)n), and about 90% of the serine residues are phosphorylated (17, 18). This enables DPP to have a strong affinity for calcium ion, and thus it significantly promotes the growth of hydroxyapatite crystals when bound to collagen fibrils in vitro.

DPP（亦称“磷磷酸蛋白”）是一种高度酸性的蛋白质，它是牙本质（13–15）中主要的非胶原蛋白基质成分。该分子之所以得名，是因为其被视为一种“磷酸载体”（16）。DPP富含天冬氨酸和丝氨酸残基（(DSS)n），其中约90%的丝氨酸残基发生磷酸化（17, 18）。这使得DPP对钙离子具有强烈的亲和力，因此在体外与胶原蛋白纤维结合时，显著促进了羟基磷灰石晶体的生长。