<p>Summary of the predicted changes in bioenergetic parameters (rows) in the presence of severe impairments in the indicated model components (columns): These predictions agree with established bioenergetic knowledge, further highlighting the accuracy of the model. Blue = decrease, white = no change, red = increase. Abbreviations: CI, complex I; CIII, complex III; CIV, complex IV; DH: Dehydrogenase flux, F1: F₁F_o ATP Synthase, Hle: Mitochondrial proton leak, KCons: Cytosolic ATP consumption, Kdyn: Cytosolic ATP production. Down arrow indicates decreased activity of the indicated component, up arrow indicates increased activity.</p>

Summary of the predicted changes in bioenergetic parameters (rows) in the presence of severe impairments in the indicated model components (columns): These predictions agree with established bioenergetic knowledge, further highlighting the accuracy of the model. Blue = decrease, white = no change, red = increase. Abbreviations: CI, complex I; CIII, complex III; CIV, complex IV; DH: Dehydrogenase flux, F1: F1Fo ATP Synthase, Hle: Mitochondrial proton leak, KCons: Cytosolic ATP consumption, Kdyn: Cytosolic ATP production. Down arrow indicates decreased activity of the indicated component, up arrow indicates increased activity.