Neurons undergo IFN?-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [snRNA-Seq]

Our study provides novel evidence that neuronal intrinsic epigenetic changes are established as a consequence of cytotoxic T cell-mediated immune attacks and persist long after the resolution of the inflammatory process and associate to long lasting synaptic loss Overall design: Single nuclear transcriptomes of neurons derived from hippocampus, from sequential timepoints of viral déjà vu disease and corresponding control in a genetic background of NuTRAP transgenic mice