Organocatalytic Kinetic Resolution of Sulfoximines
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https://figshare.com/articles/dataset/Organocatalytic_Kinetic_Resolution_of_Sulfoximines/2077960
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资源简介：
An
efficient kinetic resolution of sulfoximines with enals was realized
using chiral N-heterocyclic carbene (NHC) catalysts.
The stereoselective amidation proceeds without additional acyl transfer
agent. Both enantiomers of the sulfoximines can be obtained with excellent
ee values (up to 99% ee and −97% ee, respectively). Performing
the catalysis on a gram scale allowed using the recovered sulfoximine
(+)-1j in an asymmetric synthesis of FXa inhibitor F.
创建时间：
2016-02-04
