Pd-Catalyzed/Ligand-Controlled Regioselective Asymmetric Hydrosulfonylation of Alkylallenes or Arylallenes

The
metal-catalyzed hydrofunctionalization reaction of allenes
is an efficient approach for the construction of new allyl compounds.
This work described a palladium-catalyzed/ligand-controlled asymmetric
hydrosulfonylation of simple alkylallenes and arylallenes in the presence
of Pd2dba3. Using a Josiphos or Segphos ligand,
the alkylallenes or arylallenes could render the corresponding branched
chiral allylsulfones with high yields and high enantioselectivities
up to 90% and 99% ee, respectively.