Polycomb complexes in skin epithelium development II
收藏NIAID Data Ecosystem2026-03-14 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158322
下载链接
链接失效反馈官方服务：
资源简介：
Polycomb group (PcG) proteins are essential epigenetic transcriptional regulators. Traditionally, PcG proteins function as two multi-subunit complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3. Here, using the developing skin epidermis as a paradigm, we uncovered a functional redundancy between Polycomb complexes in the repression of unwanted non-lineage genes. Newborn mouse epidermal progenitor cells were FACS purified. Immunoprecipitated chromatin was analyzed by ChIP-seq.
创建时间：
2022-12-31
