Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders
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https://figshare.com/articles/dataset/Calcium_Phosphonate_Frameworks_for_Treating_Bone_Tissue_Disorders/2120392
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资源简介：
Two new examples of uncommon three-dimensional
Ca-bearing metal organic frameworks, [Ca(H2O)3(HPXBP)] (CaP1) and [Ca2(H2O)2(HPXBP)1.5] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures
characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination
sphere on one side of the Ca atom, while CaP2 crystallizes
in the triclinic P1̅ space group, with two
crystallographic unique Ca atoms, each coordinated by a single water
molecule. In contrast with CaP2, which exhibits very
low bioactivity, CaP1 readily precipitates bone-precursor
phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions.
Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and,
thus, holds considerable potential for treating bone diseases, such
as osteoporosis.
创建时间：
2016-02-12
