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Catalytic Asymmetric Bromoetherification and Desymmetrization of Olefinic 1,3-Diols with C2‑Symmetric Sulfides

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Figshare2016-02-17 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Catalytic_Asymmetric_Bromoetherification_and_Desymmetrization_of_Olefinic_1_3_Diols_with_i_C_i_sub_2_sub_Symmetric_Sulfides/2305573
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An enantioselective and highly diastereoselective bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C2-symmetric cyclic sulfide catalyst. This methodology has been successfully applied to the synthesis of the key intermediate of an orally active antifungal drug posaconazole (Noxafil).
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2016-02-17
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