The Integrated Quantum-Bio-Informatic Architecture (IQBIA): A Normative Framework for *De Novo* Organogenesis via Quantum Bio-Informational Programming

We present the Integrated Quantum-Bio-Informatic Architecture (IQBIA)—a rigorously constrained, first-principles theoretical framework for de novo organogenesis. IQBIA does not posit new physical laws; rather, it synthesizes three empirically plausible (though not universally established) premises: (i) non-trivial quantum coherence can persist in biological media at physiological temperatures [5,7,10]; (ii) organ morphology admits a compressed topological representation invariant under homeomorphism [3,11]; and (iii) generative artificial intelligence can learn developmental grammars from multi-omic data [8]. Under these conditions, IQBIA demonstrates that a closed-loop protocol—combining quantum information transduction, topological feedback, and field-guided self-assembly—constitutes a logically consistent pathway for organ re-specification without exogenous substrates. The framework is fully falsifiable, defines precise theoretical impossibility bounds, and generates testable predictions at the interface of quantum engineering and synthetic morphology. No funding, empirical data, or conflicts of interest are associated with this work.