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Irinotecan activates anti-tumor immunity in CT26 tumor cells

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NIAID Data Ecosystem2026-05-10 收录
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Topoisomerase I (Top1) is a classical drug target for anticancer therapy, but its role in immune signaling in cancer cells remain unclear. Here, we aimed to explore the possible role and mechanism of Irinotecan (CPT-11) in anti-tumor immunity. Overall design: mRNA expression profiles of CPT-11-treated CT26 tumor cells were generated by deep sequencing, in duplicate.

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2025-10-12
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