Crystal structure of AfOgg1-D140N mutant bound to 8-OG DNA duplex in an intermediate state

Crystal structure of AfOgg1-D140N mutant bound to 8-OG DNA duplex in an intermediate state Descriptor: 8-oxoguanine DNA glycosylase/AP lyase, DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*CP*T)-3'), ... Authors: Huffman, J.L, Tang, H.Y.H, Syed, A, Arvai, A.S, Mol, C.D, Tainer, J.A. Deposit date: 2025-04-01 Release date: 2026-04-15 Last modified: 2026-08-05 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A unified catalytic mechanism in bifunctional DNA glycosylases with an evolutionarily conserved aspartate-lysine dyad. Nat Commun, 2026