GRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3

ChEBI2014-05-22 更新2026-07-21 收录

神经母细胞瘤分子机制

肿瘤抑制基因

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GRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3

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2014-05-22

Our study showed that chromosome 1 gene mutations occur frequently in 1p-intact neuroblastoma, but these do not consistently abrogate the function of bonafide tumor suppressors residing on 1p.. Mutational Analysis of 1p Tumor Suppressors in 1p-intact Neuroblastoma

母细胞瘤遗传学

肿瘤抑制基因

Deletion of 1p is associated with poor prognosis in neuroblastoma, however selected 1p-intact patients still experience poor outcomes. Since mutations of 1p genes may produce deleterious functional ef

NIAID Data Ecosystem120

Transcription profiling of transfected A549 lung cancer cell line with new tumor supressor gen ARLTS1 in that shows a very low expression level in comparison with normal lung

肿瘤抑制基因

癌细胞转录组

We have transfected a new tumor suppresor gene named ARLTS1 in A549 lung cancer cell line that shows a very low expression level in comparison with normal lung. This line was transfected using the pMV

NIAID Data Ecosystem50

Transcriptomic analysis of neuroblastoma cells in response to stable over-expression of circular RNA derived from CUX1 gene (circ-CUX1)

神经母细胞瘤分子机制

环状RNA功能研究

Circular RNAs (circRNAs), a subclass of noncoding RNAs characterized by covalently closed continuous loops, play emerging roles in tumorigenesis and aggressiveness. However, the functions and underlyi

NIAID Data Ecosystem50

Additional file 2: Table S2. of Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study

肿瘤抑制基因

癌细胞研究

The enriched pathways and interactors for the 207 tumor suppress genes (TSGs) with frequent copy number loss (CNL). (XLSX 11 kb)

DataCite Commons2024-12-12 更新60

Datasheet1_Hsa-miR-323a-3p functions as a tumor suppressor and targets STAT3 in neuroblastoma cells.pdf

神经母细胞瘤分子机制

肿瘤抑制因子

BackgroundStudies conducted in the last decades have revealed a role for the non-coding microRNAs (miRNAs) in cancer development and progression. Several miRNAs within the chromosome region 14q32, a r

NIAID Data Ecosystem50

GRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3

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