PIMT/NcoA6IP deletion in the mouse heart causes delayed cardiomyopathy attributable to perturbation in energy metabolism. PIMT/NcoA6IP deletion in the mouse heart causes delayed cardiomyopathy attributable to perturbation in energy metabolism

Global gene expression analysis reveals that PIMT regulates many genes involved in energy metabolism, calcium signaling, and oxidative phosphorylation in myocardium. Overall design: RNA samples were prepared from hearts of 5 control PIMT floxed mice (PIMTfl/fl) and 5 Cre-loxP-mediated cardiomyocyte-specific deletion of PIMT (csPIMT-/-) mice. RNA were pooled and subjected to RNA-seq analysis.