Efficient Route to Atropisomeric Ligands – Application to the Synthesis of MeOBIPHEP Analogues
收藏数据链接：
官方服务：
资源简介：
A highly efficient Pd-catalyzed P–C coupling reaction of easily accessible atropisomeric bisphosphane is described in the presence of various electron-poor aromatic iodides. The reactions are conducted in the presence of a Pd(II)/dppf catalyst in acetonitrile at 80 °C. The reaction conditions are compatible with several electron-withdrawing groups such as esters, cyano, chloro, and trifluoromethyl groups and lead to atropisomeric MeOBIPHEP derivatives in good to excellent yields and high enantiomeric purities.
创建时间：
2016-02-23
