Macroanatomy and haemodynamic parameters (therapy-study).

The upper part of the table shows the relative (wet) weights in g/kg body weight of selected organs in the groups of the therapy-study. Non-immunised 0.9% NaCl-injected rats had no intervention (Control) or received treatment with either bisoprolol (Cont./biso.) or β1EC2-CP i.v. (Cont./EC2-CP). Similarly, immunised anti-β1EC2-positive rats remained either untreated (β1-immun.) or were treated with (oral) bisoprolol (β1-immun./biso.) or i.v.-injected with β1EC2-CP, β1EC2-Lin, or β1EC1-Lin (β1-immun./EC2-CP/ EC2-Lin/ EC1-Lin), or received β1EC2-CP/bisoprolol co-treatment (β1-immun./EC2-CP+biso.). Values given are mean weights ±SEM of heart, spleen, kidneys (R, right; L, left), lung, and liver, respectively. The lower part of the table shows invasively obtained haemodynamic parameters in the therapy-study. Parameters given are (from top to bottom, mean ±SEM): body weight (g), heart frequence (bpm), maximal systolic LV-pressure (mmHg), LV end-diastolic pressure (mmHg), contractilility (+dP/dt, mmHg/s), and relaxation (-dP/dt, -mmHg/s). One way ANOVA and Dunnett`s post-hoc testTreated vs. control*p†p‡pMacroanatomy and haemodynamic parameters (therapy-study).