Endothelin pathways
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Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2197 CPTAC Assay Portal]
内皮素-1是一种由内皮细胞主要合成的大环状21氨基酸肽。它是一种强烈的血管收缩刺激剂,可引起持久和持续的血管收缩。此外,它还充当炎症、氧化应激和细胞增殖的刺激因子。该通路上的蛋白质具有通过[CPTAC测定门户](https://assays.cancer.gov/available_assays?wp_id=WP2197)可用的靶向测定方法。
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