Two-photon calcium imaging of mouse posterior cortical areas during dynamic navigation decisions (Tseng et al., 2022, Neuron)

This is the dataset for Tseng et al, "Shared and specialized coding across posterior cortical areas for dynamic navigation decisions" in Neuron (2022). The dataset contains calcium activity of >200,000 neurons recorded from 6 different cortical areas in mouse posterior cortex L2/3 and L5 using two-photon imaging, including V1 and secondary visual areas, retrosplenial cortex (RSC) and posterior parietal cortex (PPC), while the mice were performing a flexible decision-making task based on rule-switching during virtual navigation. There are total 300 behavior + imaging sessions collected from 8 mice. The neurons in each experiment have been registered into the Allen Institute Mouse Common Coordinate Framework (CCF) based on widefield retinotopy. In addition, these neurons contain fluorescent labels of retroAAV injected in one of the two sets of projection targets: an anterior part of anterior cingulate cortex/secondary motor cortex (ACC/M2) and striatum, or a posterior part of ACC/M2 and orbitofrontal cortex (OFC).

Please see the related paper for more details: https://doi.org/10.1016/j.neuron.2022.05.012

Additional resources:

- Jupyter notebook for a tutorial to read and extract information from these NWB files: https://github.com/sytseng/Notebook_for_Dandiset_000579

- NWB extension code for custom lab meta data (required for reading NWB files): https://github.com/sytseng/ndx-harvey-swac

- Code and tutorials for fitting GLM to neural activity in Tensorflow 2: https://github.com/sytseng/GLM_Tensorflow_2