Identification of Two Subgroups of FOLFOX Resistance Patterns and Prediction of FOLFOX Response in Colorectal Cancer Patients
收藏DataCite Commons2021-05-07 更新2024-07-28 收录
下载链接：
https://tandf.figshare.com/articles/dataset/Identification_of_Two_Subgroups_of_FOLFOX_Resistance_Patterns_and_Prediction_of_FOLFOX_Response_in_Colorectal_Cancer_Patients/13312889/1
下载链接
链接失效反馈官方服务：
资源简介：
To dissect gene expression subgroups of FOLFOX resistance colorectal cancer(CRC) and predict FOLFOX response, gene expression data of 83 stage IV CRC tumor samples (FOLFOX responder <i>n</i> = 42, non-responder <i>n</i> = 41) are used to develop a novel iterative supervised learning method IML. IML identified two mutually exclusive subgroups of CRC patients that rely on different DNA damage repair proteins and resist FOLFOX. IML was validated in two validation sets (HR = 2.6, <i>p</i> Value = 0.02; HR = 2.36, <i>p</i> value = 0.02). A subgroup of mesenchymal subtype patients benefit from FOLFOX. Different subgroups of FOLFOX nonresponders may need to be treated differently.
提供机构：
Taylor & Francis
创建时间：
2020-12-01
