File S1 - Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy

Combined file of supporting figures and tables. Table S1: Data collection and refinement statistics. Figure S1: Electron density for compound 1294 (15o) in the active site of NcCDPK1. Green density cages are difference electron density from an initial map calculated prior to adding the inhibitor to the structural model (3 sigma contours). Blue density cages are mFo-Fc density after refinement of the protein and inhibitor. Figure S2: Electron density for compound RM-1-132 (15n) in the active site of NcCDPK1. Green density cages are difference electron density from an initial map calculated prior to adding the inhibitor to the structural model (3 sigma contours). Blue density cages are mFo-Fc density contoured at 2.5 sigma after refinement of the protein and inhibitor. The faint purple trace is a superposition of the same compound as bound in the active site of the homologous TgCDPK1. (DOCX)